We Have Beds Available! Call for Same Day Admission.855-722-6926
We Have Beds Available! Call for Same Day Admission.855-722-6926

Oxymorphone vs. Hydromorphone

Oxymorphone and hydromorphone are two types of narcotics used to treat severe pain and as an anesthetic in some cases.

While both are used in the medical field, they both have a high potential for abuse and addiction. Today, our Delaware drug rehab compares oxymorphone vs. hydromorphone to find out the differences and risks associated with their misuse.

What Is Oxymorphone?

Also known as Opana and Opana ER, oxymorphone is a prescription opioid that’s used to treat moderate to severe pain. Opana may also be used as a supplement to anesthesia during surgery and to alleviate anxiety caused by heart-related breathing problems.

Oxymorphone comes as an extended-release (long-acting) tablet that’s taken by mouth at least an hour before or two hours after meals and is usually taken every 4 to 6 hours. Extended-release opioids are usually only taken once or twice a day because their side effects are long-acting.

Opana is usually only prescribed to people who do not respond to other painkillers and are usually prescribed a small dose at the beginning, with a steady and slight increase in doses as time progresses.

Like other narcotic analgesics, oxymorphone attaches to opioid receptors in the central nervous system to alleviate pain. However, when taken in ways that it’s not supposed to be taken – such as chewing them or taking them with alcohol – medications like oxymorphone can produce intense euphoria and sedation.

Other common oxymorphone side effects include:

  • Dry mouth
  • Stomach pain or swelling
  • Nausea and/or vomiting
  • Gas
  • Excessive sweating
  • Sedation
  • Dizziness
  • Lightheadedness
  • Impaired judgment and concentration
  • Flushing of the skin
  • Low blood pressure
  • Anxiety and confusion
  • Itching

Changes in heart rate, weight loss, agitation, hallucinations, fever, and other adverse side effects may also occur when Opana is taken in ways it’s not meant to be taken.

Crushing your pills, snorting them, chewing them, and mixing them with alcohol all constitute drug abuse. Engaging in this kind of drug-taking behavior increases your risk of addiction and other long-term health problems.

Questions about our Facilities or Programs?

Our admissions coordinators are available 24/7 to answer any questions you may have as you consider whether treatment at Banyan is right for you or your loved one.

What Is Hydromorphone?

Also referred to as Exalgo ER and Dilaudid, hydromorphone is also an opioid that’s prescribed for moderate to severe pain treatment. Hydromorphone extended-release tablets are prescribed to people with severe and chronic pain who need round-the-clock relief or cannot be treated with other medications.

This medication is not prescribed to people who need short-term pain relief or have never taken other opioids before. Hydromorphone may come as a liquid, a tablet, and an extended-release tablet. The liquid is usually taken every 3 to 6 hours and the tablets every 4 to 6 hours.

Like oxymorphone, people who take hydromorphone usually start with small doses that are slowly increased over time. This medication also works like oxymorphone in that it attaches to opioid receptors on nerve cells, blocking pain signals from the body.

However, hydromorphone can also produce a high when taken in high doses or mixed with other central nervous system depressants. Hydromorphone side effects may also include:

  • Dry mouth
  • Difficulty falling or staying asleep
  • Nausea and/or vomiting
  • Excessive sweating
  • Sedation
  • Dizziness
  • Constipation
  • Lightheadedness
  • Impaired judgment and concentration
  • Flushing of the skin
  • Low blood pressure
  • Anxiety and confusion
  • Rash
  • Hives
  • Itching
  • Depression
  • Muscle, back, or joint pain
  • Decreased sexual drive
  • Fainting
  • Irregular menstruation
  • Erectile dysfunction

Although Opana and Dilaudid share some side effects, the drugs are slightly different, and these differences can impact the way they should be used and prescribed.

What Is the Difference Between Hydromorphone and Oxymorphone?

The difference between hydromorphone and oxycodone is that hydromorphone is stronger than oxymorphone, making it more potent and addictive. Some other differences between Opana and Dilaudid include:

  • Dilaudid works better and provides faster pain relief
  • Dilaudid tends to cause constipation, which may require the use of laxatives or stool softeners
  • Hydromorphone is fatal when mixed with alcohol, muscle relaxants, and other depressants
  • Dilaudid is available in more formulations, including short and long-acting pills, liquid, and suppository

What about their potency? Is Opana stronger than Dilaudid?

These slight differences are important when it comes to prescribing patients with the right medication. When comparing oxymorphone vs. hydromorphone, research suggests that hydromorphone is much stronger than oxymorphone, meaning that less of it is needed to alleviate symptoms.

Hydromorphone is also four times more potent than morphine, making it a more likely candidate for those searching for an alternative to other opioids, even illicit ones like heroin. Thus, those who abuse hydromorphone are at a higher risk of developing an addiction, overdosing, and dying from health complications associated with drug abuse.

Getting into treatment is easy with our free insurance verification

"*" indicates required fields

This field is for validation purposes and should be left unchanged.

Getting Help for Opioid Addiction

Regardless of whether they’re prescribed or not, opioids are known for their high potential for abuse and addiction. The mass abuse of these drugs has contributed to a major opioid crisis, which has resulted in thousands of opioid-related overdoses and deaths.

If you’ve been directly impacted by opioid abuse, our Milford treatment center can help. Banyan Delaware offers various levels of substance abuse treatment, including drug-specific services like opioid addiction treatment.

From medical detox to physical and mental health therapy, specialists at our Milford rehab provide the round-the-clock care and services needed to get sober and stay sober. For more information about our Delaware addiction treatment, call Banyan Treatment Centers today at 888-280-4763.



Related Reading:

List of Opioids Strongest to Weakest
Brorphine HCL: The New Opioid on The Street

Alyssa, Director of Digital Marketing
Alyssa, Director of Digital Marketing
Alyssa is the National Director of Digital Marketing and is responsible for a multitude of integrated campaigns and events in the behavioral health and addictions field. All articles have been written by Alyssa and medically reviewed by our Chief Medical Officer, Dr. Darrin Mangiacarne.