Written by: Banyan Editorial Staff   |   Medically reviewed by: Dr. Darrin Mangiacarne - Chief Medical Officer   |   Edited: February 2025 

Recovery is not easy. After detox, many people still crave alcohol or opioids for months or years. These cravings can make staying sober difficult. Vivitrol gives medical support to strengthen recovery and offers a safe, effective solution.

At Banyan Treatment Centers, we include Vivitrol (naltrexone) in medically supervised addiction treatment. This FDA-approved drug blocks the high from opioids and alcohol and reduces cravings, so you can focus on healing.[2]

What Is Vivitrol and How Does It Work?

Vivitrol is the brand name for naltrexone, an extended-release injectable medication designed to help people recovering from opioid or alcohol dependence. It functions as an opioid receptor antagonist, meaning it binds to the brain’s opioid receptors without activating them.[1] By blocking these receptors, Vivitrol prevents opioids like heroin, morphine, or oxycodone from producing pleasurable effects.

For individuals recovering from alcohol use disorder, Vivitrol for alcohol helps reduce cravings by interfering with the brain’s reward response to drinking. This makes it easier to maintain sobriety and avoid relapse triggers.

How Does Naltrexone Work?

Naltrexone helps the brain unlearn the cycle of craving and reward associated with substance use. Over time, this can decrease the psychological pull of addiction. When used alongside therapy and support programs, it provides a stable foundation for long-term recovery.

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Vivitrol vs. Suboxone: What’s the Difference?

Both Vivitrol and Suboxone are used to treat opioid use disorder, but they differ in how they work:

  • Vivitrol (Naltrexone): A non-addictive, once-monthly injection that blocks opioid effects and reduces alcohol cravings.
  • Suboxone (Buprenorphine and Naloxone): A partial opioid agonist taken daily that helps reduce withdrawal symptoms and cravings.

Unlike Suboxone, Vivitrol is not an opioid-based medication and has no potential for misuse. It’s ideal for those who have already completed detox and are ready to focus on maintaining sobriety.[3]

Vivitrol Prescribing Requirements

Before beginning Vivitrol treatment, patients must be completely free of opioids and alcohol for at least 7 to 14 days to avoid sudden withdrawal symptoms.[1] It’s crucial to undergo a medically supervised detox to ensure the body is fully clear of substances.

Vivitrol is not recommended for individuals currently using opioids, taking prescription painkillers, or drinking alcohol. Combining naltrexone with active substance use can lead to severe side effects or overdose.

After detox, Vivitrol may be integrated into a personalized recovery plan that includes therapy, counseling, and relapse prevention support.

Understanding Vivitrol and Naltrexone Side Effects

Vivitrol is generally well-tolerated, and naltrexone side effects are usually mild. Common symptoms can include:

  • Headaches or dizziness
  • Nausea or vomiting
  • Fatigue or weakness
  • Anxiety or restlessness
  • Loss of appetite or weight changes
  • Muscle cramps or joint pain

More serious side effects, while rare, can include liver inflammation, injection site reactions, or low mood.[1] Anyone experiencing these symptoms should contact a healthcare provider immediately.

Vivitrol is a non-addictive medication for alcoholism and opioid addiction, but it must be administered under medical supervision to ensure safety.

Important: Never take Vivitrol while opioids are still in your system. Doing so can trigger severe withdrawal.

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Vivitrol and Relapse Prevention

One of the most powerful benefits of Vivitrol is its role in relapse prevention. Because it blocks the euphoric effects of alcohol and opioids, even if a person attempts to use, they will not experience the expected high. This interruption of the reward cycle helps protect recovery progress.

For those recovering from alcohol addiction, Vivitrol also reduces cravings, giving the brain time to heal from the effects of long-term substance use. When combined with therapy and counseling, it supports emotional stability and long-term recovery success.

Integrating Vivitrol with Holistic Addiction Therapy

Vivitrol addresses the physical aspects of addiction, but recovery also involves mental, emotional, and social healing. That’s why it’s often combined with therapeutic approaches like:

  • Cognitive Behavioral Therapy (CBT) for managing thought patterns.
  • Biofeedback and mindfulness therapies to reduce stress.
  • Group and family therapy to rebuild relationships.

When paired with comprehensive care, Vivitrol helps individuals regain control over cravings while developing the coping skills needed to maintain sobriety.

Frequently Asked Questions

1What is naltrexone used for?
Naltrexone treats opioid and alcohol dependence by reducing cravings and blocking pleasurable effects. It helps people avoid relapse and maintain sobriety.
2Is naltrexone a controlled substance?
No. Naltrexone is not a controlled substance and cannot be misused or cause dependence. It is a safe, non-addictive option for recovery.[5]
3What are common and low-dose naltrexone side effects?
Common naltrexone and Vivitrol side effects include nausea, fatigue, and headache. Some people using low-dose naltrexone may experience vivid dreams or mild stomach discomfort, but these effects are typically temporary. Always consult your healthcare provider before starting or adjusting your dose.
4What to avoid when taking naltrexone?
While taking Vivitrol or naltrexone, you should avoid: Using opioids or alcohol (even in small amounts). Taking opioid-containing medications, such as certain cough syrups or painkillers. Skipping or delaying injections without consulting your provider. These precautions help prevent withdrawal symptoms and ensure treatment remains effective.
5What happens if you drink alcohol while on Vivitrol?
Vivitrol blocks alcohol’s pleasurable effects, but drinking can still cause intoxication and health risks. Because it doesn’t prevent physical impairment, it’s best to avoid alcohol entirely during treatment.
6How long does the Vivitrol shot last?
Each Vivitrol injection lasts about 28 to 30 days. To maintain consistent protection against cravings, injections should be scheduled once a month.[4]
7Can Vivitrol be reversed?
No. Once injected, Vivitrol remains active for about a month. There’s no immediate way to remove it from the system, so patients should inform healthcare providers before any surgery or emergency treatment requiring pain management.
8How can I start Vivitrol treatment at Banyan Treatment Centers?
If you or someone you love is interested in Vivitrol treatment, contact Banyan Treatment Centers today. Our medical team will review your history, determine if Vivitrol is appropriate, and design a personalized recovery plan. Call us now for a free, confidential consultation at (855) 908-0663 and take the first step toward lasting recovery.

A Step Toward Lasting Sobriety

Vivitrol offers hope for those seeking a medication-based path to recovery. By reducing cravings and blocking the effects of drugs and alcohol it allows individuals to focus on rebuilding their lives and maintaining sobriety. When used alongside professional therapy and support, Vivitrol can be a life-changing component of long-term recovery.

Sources:

  1. FDA – Drug Approval Package – Vivitrol
  2. Verywell Mind – Vivitrol Treatment for Alcoholism and Addiction
  3. Vivitrol – Prescribing Information

Related Reading:

Sources

  1. VIVITROL (naltrexone for extended-release injectable suspension), for intramuscular use - Prescribing Information. Alkermes, Inc.. U.S. Food and Drug Administration (FDA), 2018.
  2. VIVITROL (naltrexone for extended-release injectable suspension) prescribing information. Alkermes, Inc.. FDA, 2010.
  3. Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT): a multicentre, open-label, randomised controlled trial. Lee JD, Friedmann PD, Kinlock TW, et al.. The Lancet, 2018. DOI: 10.1016/S0140-6736(17)32812-X.
  4. VIVITROL (naltrexone for extended-release injectable suspension) Prescribing Information. U.S. Food and Drug Administration. FDA Center for Drug Evaluation and Research, 2022.
  5. Naltrexone - StatPearls - NCBI Bookshelf. Parashar N, O'Neill J, Gupta R, et al.. StatPearls [Internet], 2023.

Medically Reviewed by:

Dr. Darrin Mangiacarne
Chief Medical Officer